What Drugs Should Not Be Taken With CBD?

What Drugs Should Not Be Taken With CBD?

Potential Drug Interactions with CBD: What You Need to Know

When considering the use of CBD (cannabidiol), it is essential to be aware of potential drug interactions. CBD can interact with several medications primarily because it is metabolized by the liver's cytochrome P450 enzyme system, which is responsible for metabolizing many drugs. Here are some common categories and specific medications that may interact with CBD, along with reasons why caution is advised:

Drugs to avoid taking with CBD

Blood Thinners

  • Medications: Warfarin (Coumadin), Clopidogrel (Plavix), Apixaban (Eliquis), Dabigatran (Pradaxa), Rivaroxaban (Xarelto)
  • Why to Avoid with CBD: CBD can increase the blood-thinning effects of these medications, leading to an increased risk of bleeding and bruising. This happens because CBD inhibits the enzyme CYP2C19, which is responsible for metabolizing many blood thinners, potentially causing higher levels of the drug in the bloodstream.

Anti-seizure Medications

  • Medications: Clobazam (Onfi), Valproate (Depakote), Phenytoin (Dilantin), Carbamazepine (Tegretol), Lamotrigine (Lamictal)
  • Why to Avoid with CBD: CBD can either increase or decrease the effectiveness of anti-seizure medications. For example, it can increase the levels of Clobazam in the blood, leading to excessive sedation and other side effects, while it may decrease the effectiveness of other seizure medications by altering their metabolism.

Antidepressants and Antipsychotics

  • Medications: SSRIs (e.g., fluoxetine, sertraline), SNRIs (e.g., venlafaxine, duloxetine), Tricyclic antidepressants (e.g., amitriptyline, nortriptyline), Antipsychotics (e.g., risperidone, haloperidol, olanzapine)
  • Why to Avoid with CBD: CBD can enhance the effects of these medications, potentially leading to increased side effects such as drowsiness, dizziness, and confusion. This is due to CBD's ability to inhibit the enzyme CYP2D6, affecting the metabolism of many antidepressants and antipsychotics.


  • Medications: Macrolides (e.g., erythromycin, clarithromycin), Rifampicin
  • Why to Avoid with CBD: CBD can interfere with the metabolism of certain antibiotics, leading to higher levels of the drugs in the body and increasing the risk of side effects. Conversely, some antibiotics may also alter the metabolism of CBD, affecting its efficacy.


  • Medications: Ketoconazole, Itraconazole
  • Why to Avoid with CBD: Antifungal medications are strong inhibitors of the CYP3A4 enzyme, which is crucial for the metabolism of CBD. Combining them can lead to significantly increased levels of CBD, enhancing both its effects and side effects.


  • Medications: Cyclosporine, Tacrolimus
  • Why to Avoid with CBD: CBD can increase the blood levels of immunosuppressants, potentially leading to toxicity. This is critical for patients who have undergone organ transplants and rely on precise dosing to prevent organ rejection.

Heart Medications

  • Medications: Calcium channel blockers (e.g., amlodipine, verapamil), Beta-blockers (e.g., metoprolol, propranolol)
  • Why to Avoid with CBD: CBD can interact with heart medications, leading to altered heart rate and blood pressure. This is due to its impact on the metabolism of these drugs, which can either amplify or reduce their effects.


  • Medications: Morphine, Oxycodone, Fentanyl
  • Why to Avoid with CBD: CBD can increase the sedative effects of opioids, leading to enhanced drowsiness, respiratory depression, and potentially dangerous sedation. This interaction is due to CBD's influence on the CYP3A4 enzyme system.


  • Medications: Diazepam (Valium), Alprazolam (Xanax), Lorazepam (Ativan)
  • Why to Avoid with CBD: CBD can slow the metabolism of benzodiazepines, increasing their sedative effects and the risk of side effects such as extreme drowsiness and confusion. This is mainly due to the inhibition of the CYP3A4 enzyme by CBD.

Other Medications

  • Medications: Proton pump inhibitors (e.g., omeprazole), Antihistamines (e.g., diphenhydramine), NSAIDs (e.g., ibuprofen, naproxen)
  • Why to Avoid with CBD: CBD can alter the metabolism of these medications, leading to either increased side effects or reduced effectiveness. For example, CBD can enhance the effects of antihistamines, causing excessive drowsiness, or affect the efficacy of NSAIDs, potentially leading to gastrointestinal issues.
Doctor Consultation about CBD

Importance of Consulting with Your Doctor

  1. Personalized Medical Advice: Your doctor understands your medical history, current health conditions, and medications you are taking, providing tailored advice on whether CBD tinctures are safe and appropriate for you.

  2. Potential Drug Interactions: CBD can interact with various medications, affecting their efficacy and safety. Your doctor can evaluate these interactions and adjust dosages or suggest alternatives if necessary.

  3. Dosage Guidance: Determining the right CBD dosage varies based on factors like body weight, metabolism, and the condition being treated. Your doctor can help you start with a safe dosage and adjust it based on your response.

  4. Monitoring Side Effects: While CBD is generally considered safe, it can cause side effects such as fatigue, diarrhea, and changes in appetite. Your doctor can monitor for these and provide guidance on managing them.

  5. Underlying Health Conditions: Certain health conditions, like liver disease, can be affected by CBD use. Your doctor can assess whether your specific health conditions might be exacerbated by CBD and advise accordingly.

  6. Quality and Safety of CBD Products: The CBD market is not strictly regulated, leading to variability in product quality and labeling accuracy. Your doctor can help you identify reputable brands and products that have been tested for safety and efficacy.

  7. Legal Considerations: The legality of CBD varies by region. Your doctor can provide information on the legal status of CBD in your area and any potential implications for your treatment.

  8. Holistic Approach to Treatment: Your doctor can help integrate CBD into your overall treatment plan, ensuring it complements other therapies and lifestyle changes.

  9. Addressing Misconceptions: There is a lot of misinformation about CBD. Consulting with your doctor can help clarify any misconceptions and provide evidence-based information about its potential benefits and risks.

  10. Regular Monitoring and Follow-Up: Regular follow-up appointments with your doctor allow for ongoing monitoring of your response to CBD, making necessary adjustments to your treatment plan for optimal health outcomes.

CBD and Medication FAQ's

  1. Can I take CBD with over-the-counter medications?

    • While some over-the-counter medications may not have severe interactions with CBD tinctures, it's crucial to consult with a healthcare provider to avoid any potential risks, especially if you are taking other prescription medications.
  2. What should I do if I experience side effects from taking CBD Pain cream with my medication?

    • If you experience side effects, contact your doctor immediately. They can adjust your dosage or suggest an alternative treatment plan.
  3. Is it safe to use CBD with herbal supplements?

    • Herbal supplements can also interact with CBD. It's important to discuss any supplements you are taking with your doctor to ensure there are no adverse interactions.
  4. How long after taking medication should I wait before using CBD?

    • The timing can vary depending on the medication. Your doctor can provide specific guidance based on your treatment plan and the medications you are taking.
  5. Can CBD replace my current medications?

    • CBD should not be used as a replacement for prescribed medications without consulting your doctor. It may be used as a complementary therapy, but only under professional medical guidance.